Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair
نویسندگان
چکیده
منابع مشابه
Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair
Background We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However, regenerative medicine with autologous chondrocyte sheets requires the harvesting of tissue from healthy regions, and the quality of this tissue varies between individuals. To ...
متن کاملThe effects of using vitrified chondrocyte sheets on pain alleviation and articular cartilage repair.
The effect of using vitrified-thawed chondrocyte sheets on articular cartilage repair was examined because the methods for storing chondrocyte sheets are essential for allogeneic chondrocyte sheet transplantation. Six Japanese white rabbits were used as sources of articular chondrocytes and synovial cells. Chondrocytes were harvested from the femur, and synovial cells were harvested from inside...
متن کاملRepair of articular cartilage defect with layered chondrocyte sheets and cultured synovial cells.
In this study, we investigate the effects of treatment with layered chondrocyte sheets and synovial cell transplantation. An osteochondral defect was created of 48 Japanese white rabbits. In order to determine the effects of treatment, the following 6 groups were produced: (A) synovial cells (1.8 × 10(6) cells), (B)layered chondrocyte sheets (1.7 × 10(6) cells), (C) synovial cells (3.0 × 10(5) ...
متن کاملThe properties of bioengineered chondrocyte sheets for cartilage regeneration
BACKGROUND Although the clinical results of autologous chondrocyte implantation for articular cartilage defects have recently improved as a result of advanced techniques based on tissue engineering procedures, problems with cell handling and scaffold imperfections remain to be solved. A new cell-sheet technique has been developed, and is potentially able to overcome these obstacles. Chondrocyte...
متن کاملChondrocyte ultrastructure in adult human articular cartilage.
Age changes in the ultrastructure of articular chondrocytes have been studied in detail in mice (Silberberg, Silberberg, and Feir, 1964) and in rabbits (Davies, Barnett, Cochrane, and Palfrey, 1962; Barnett, Cochrane, and Palfrey, 1963). Less has been published concerning the influence of age on cellular ultrastructure in human articular cartilage. This is due partly to the scarcity of suitable...
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ژورنال
عنوان ژورنال: Inflammation and Regeneration
سال: 2017
ISSN: 1880-8190
DOI: 10.1186/s41232-017-0053-6